Endocrine Abstracts

Precedents: Thirty-nine year old Woman. Classic phenylketonuria diagnosed for neonatal screening in Germany. Good adherence to the diet from the infancy, with good metabolic control. Not response to test with BH4.Pregnancy in 2007 with good controls of phenylalanine (Phe). Son with congenital cardiopathy.Evolution: In 2013 she planed new pregnancy, departing from very good controls (<4 mg/dl) and ingestion of 22–24 Phe&#14...

Introduction: Parenteral nutrition (PN) is indicated in patients in which gastrointestinal tract is inaccessible or is severely affected. In our hospital, specialists often use commercial three-compartment bags of PN that provide standard nutritional requirements regardless a total parenteral nutrition (TPN) with macro and micronutrients adjusted to each patient by Endocrinology and Nutrition Service.Objectives: To assess the use of commercial premixed P...

Introduction: Pituicytoma is a low-grade glioma of the suprasellar and sellar regions that is rarely described (about 60 cases described in the literature). The clinical, laboratory and neuroradiological findings are not pathognomonic, and therefore definitive diagnosis is only possible after surgery and histopathological study. Total resection is the treatment of choice, since subtotal removal can often lead to recurrence or progression.Case report: We ...

Introduction: The objective is to evaluate the relationship between precocious subclinical hypertension and inflammatory and endothelial dysfunction markers in normotensive and normoalbuminuric patients with type 1 diabetes.Methods: We designed an observational transversal study of 85 patients, clinically normotensive and without microalbuminuria. Ambulatory blood pressure monitoring (abpm) was performed over 24 h and subclinical hypertension was conside...

Introduction: Pituicytoma is a low-grade glioma of the suprasellar and sellar regions that is rarely described (about 60 cases in the literature). The clinical, laboratory, and neuroradiological findings are not pathognomonic, and therefore definitive diagnosis is only possible after surgery and histopathological study. Total resection is the treatment of choice, since subtotal removal can often lead to recurrence or progression.Case report: We report th...

Objectives: To evaluate the prevalence of blood pressure alterations with ambulatory blood pressure monitoring (ABPM) and its association with proinflammatory cytokines (IL-6 and VEGFα) in normotensive and normoalbuminuric patients with type 1 diabetes (TDM1).Patients and methods: Cross-sectional study including normotensive and normoalbuminuric patients with TDM1. Altered ABPM was considered when: 1) Mean systolic pressure (sBP) was greater than 13...

Objective: To evaluate changes of ambulatory blood pressure monitoring (ABPM) parameters in normotensive and normoalbuminuric patients with type 1 diabetes (TDM1) after 7 years.Methods: A longitudinal study conducted in normotensive and normoalbuminuric patients with TDM1. ABPM (Spacelabs 90217) basal was performed. Altered ABPM was considered when: i) Mean systolic pressure (sBP) was ≥130 mmHg in the 24 h and daytime periods and ≥120 mmHg in...

Background and aim: Obesity (Ob) is tightly associated with metabolic diseases such as type 2 diabetes (DT2) andinsulin resistance (IR). Furthermore, obesity has been identified as one of the primary causes of mood disorders (MDs) including depression. Several studies have demonstrated the link between Ob, adiposity, neuroinflammation and MDs. The Brain-Derived Neurotrophic Factor (BDNF) and its regulator, the non-coding RNA BDNF antisense RNA (BDNFas), play an import...

Background: Obesity has been associated with low levels of 25-hydroxyvitamin D (25(OH)D). This could be explained by a low dietary intake, reduced sun exposure or less biodisponibility because of its arrest in the fat mass. The main objective is to study the prevalence of 25(OH)D deficiency in premenopausal obese women.Methods: Aleatory sample of 100 morbidly obese patients. Selection criteria were: women, premenopausal, Caucasian. Patient with diabetes ...

Introduction: The treatment of differentiated thyroid carcinoma exposes most patients to chronic supraphysiological doses of thyroid hormone which seems to have several negative effects for the patient. The goal of the present study was to assess the consequences of these doses on the bone mineral density (BMD).Patients and methods: We performed a cross-sectional study on 64 female patients followed up between 1972 and 2007. We registered the levothyroxi...